For the development of healthy, functional skin, the hormones, melatonin and cortisol are critical, but how can skin care professionals detect when they go off course? What skin issues are brought on by excessive cortisol levels or a melatonin deficiency? It is important to understand the essential functions of cortisol and melatonin to provide insight into healthy functioning skin. Want to read more? Subscribe to continue reading this article, plus gain access to all DERMASCOPE has to offer. SUBSCRIBE References Kresser, C. (2019, October 10). What really causes oxidative damage?. Kresser Institute. https://kresserinstitute.com/what-really-causes-oxidative-damage/ Tarocco, A., Caroccia, N., Morciano, G., Wieckowski, M. R., Ancora, G., Garani, G., & Pinton, P. (2019). Melatonin as a master regulator of cell death and inflammation: Molecular mechanisms and clinical implications for newborn care. Cell Death & Disease, 10(4). https://doi.org/10.1038/s41419-019-1556-7 Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., & Xu, B. (2018). Mitochondria: Central organelles for melatonin′s antioxidant and anti-aging actions. Molecules, 23(2), 509. https://doi.org/10.3390/molecules23020509 Kauppila, T. E. S., Kauppila, J. H. K., & Larsson, N.-G. (2017). Mammalian mitochondria and aging: An update. Cell Metabolism, 25(1), 57–71. https://doi.org/10.1016/j.cmet.2016.09.017 Poljšak, B., & Dahmane, R. (2012). Free radicals and extrinsic skin aging. Dermatology Research and Practice, 2012. https://doi.org/10.1155/2012/135206 Silva, S. A., Michniak-Kohn, B., & Leonardi, G. R. (2017). An overview about oxidation in clinical practice of skin aging. Anais Brasileiros de Dermatologia, 92(3), 367–374. https://doi.org/10.1590/abd1806-4841.20175481 Poljšak, Borut & Dahmane, Raja & Godic, Aleksandar. (2012). Intrinsic skin aging: The role of oxidative stress. Acta dermatovenerologica Alpina, Panonica, et Adriatica. 2012;21:1-4. 1-4. 10.2478/v10162-012-0012-5. Reiter, R. J., Tan, D. X., Kim, S. J., & Cruz, M. H. (2014). Delivery of pineal melatonin to the brain and SCN: Role of Canaliculi, cerebrospinal fluid, tanycytes and Virchow–Robin Perivascular Spaces. Brain Structure and Function, 219(6), 1873–1887. https://doi.org/10.1007/s00429-014-0719-7 Want to read more? Subscribe to one of our monthly plans to continue reading this article.