AIM at Melanoma announces the grand opening of the first branch of the International Melanoma Tissue Bank Consortium (IMTBC) at the University of Pittsburgh Medical Center (UPMC), Hillman Cancer Center. The Pittsburgh site is one of six global locations of the consortium. These six institutions and their researchers will collect a critical mass of fresh-frozen primary tumor tissue for collaborative research, with a goal of 500 samples collected in the next two years. A fresh-frozen primary tissue bank – fully annotated and collaborative – has never been achieved before in melanoma and it has taken more than a decade of dedicated work to accomplish. The IMTBC is a global first because of the following combination of factors:
• It is a consortium – the six institutions are sharing data and tissue samples with each other
• It is collaborative – tissue samples and data will be available for researchers around the world to apply to study
• The tissue will be fresh-frozen – RNA is preserved, unlike in the standard formalin fixed, paraffin embedded process
• The tumors are primary – not metastasized
• There will be a critical mass – a goal of 500 in the first two years and continued collection thereafter
• Full annotation will accompany each tissue – patient data, including full medical history (depersonalized) will be available for study along with the tissue
• Samples will accompany each tissue – blood and urine samples will be collected for each patient
“The primary tumor is the holy grail of resources for melanoma researchers,” says John M. Kirkwood, MD, usher professor of medicine, dermatology, and translational science and co-leader of the melanoma and skin cancer program at UPMC Hillman Cancer Center. “We know the information we seek about melanoma is available in primary tumors, but researchers need a critical mass of fresh-frozen tissue and all the relevant patient data to understand it. We believe fresh-frozen primary tissue can help us discover the answers we seek, such as: whose melanomas will spread and become deadly; who will respond to immunotherapies; and, ultimately, how we can cure this disease.”
UPMC Hillman Cancer Center is one of six branches of the IMTBC – four in the United States and two in Australia. The remaining locations have approved their contracts to become fully functioning branches of the IMTBC and are awaiting only final details before they, too, will open and accelerate the collection of tissue.
“Fifteen years ago, many researchers told me that a collaborative fresh-frozen primary tissue bank would propel research, but they also told me it would be impossible to accomplish,” says Val Guild, the founder and president of AIM at Melanoma, who lost her 26-year-old daughter, Charlie, to the disease in 2003. “And, there were times over the years that I felt like giving up. But, I’m extremely proud to announce this grand opening of the UPMC branch of the International Melanoma Tissue Bank Consortium today, on what would have been my daughter Charlie’s 42nd birthday. I believe the IMTBC will help us get to the place where no family suffers as we did.”