In 1981, the FDA approved bovine collagen for cosmetic injection. Since its approval, dozens of injectable fillers have been developed and approved for cosmetic use. The first filling agents were formulated to help with therapy-induced facial fat loss and lipoatrophy in HIV patients; however, some physicians started administering fillers to their patients seeking cosmetic rejuvenation. The injectable poly-l-lactic acid was the filler of choice at the time, lasting up to three years with maintenance.

Dasha Saian Marchese is the co-founder and CEO of Saian and has over 22 years of experience in the spa industry. She is a licensed aesthetician, AIA ambassador, and serves on the editorial advisory board of DERMASCOPE magazine. In addition to her aesthetics schooling, Saian Marchese has a degree in business and marketing. She gives lectures and classes internationally and regularly contributes to global trade publications.